Rejuvenating tithonus.

نویسندگان

  • Kyle M Loh
  • Bing Lim
چکیده

Tennyson tells us of Tithonus, who was endowed with immortality and was never permitted to perish, despite his wishes to that end. A biological parallel might be pluripotent stem cells, which can be indefinitely propagated in vitro in an uncommitted, self-renewing state, and can form all lineages in the mammalian body [1]. However, pluripotency is an inherently transient condition in vivo. Thus, pluripotent cells in vitro, such as embryonic stem cells (ESCs), continually show proclivities towards differentiation, similarly to Tithonus seeking the termination of his immortality [1]. To counteract this, several molecular actors, including the transcription factor Prdm14, within self-renewing pluripotent cells restrain forward developmental progression [2,3]. Four papers, including one in this issue of EMBO reports, depict mechanisms by which Prdm14 serves as the elixir of youth for pluripotent stem cells [4–7], acting at the levels of developmental signalling and chromatin.

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عنوان ژورنال:
  • EMBO reports

دوره 14 7  شماره 

صفحات  -

تاریخ انتشار 2013